PT - JOURNAL ARTICLE AU - Williams, Justin C. AU - Denison, Timothy TI - From Optogenetic Technologies to Neuromodulation Therapies AID - 10.1126/scitranslmed.3003100 DP - 2013 Mar 20 TA - Science Translational Medicine PG - 177ps6--177ps6 VI - 5 IP - 177 4099 - http://stm.sciencemag.org/content/5/177/177ps6.short 4100 - http://stm.sciencemag.org/content/5/177/177ps6.full AB - The field of optogenetics has provided new insight into neuronal communication and complex brain function. Now, scientists eagerly anticipate clinical application of this technology, with the hope that it will help improve treatments for various neurological disorders. However, the translational hurdles are high. In this Perspective, we highlight the technical, practical, and regulatory hurdles that lie ahead along the path towards making optogenetic neuromodulation therapies a reality in the clinic.