RT Journal Article SR Electronic T1 Response to Comment on “Community-Wide Isoniazid Preventive Therapy Drives Drug-Resistant Tuberculosis: A Model-Based Analysis” JF Science Translational Medicine FD American Association for the Advancement of Science SP 204lr4 OP 204lr4 DO 10.1126/scitranslmed.3007442 VO 5 IS 204 A1 Mills, Harriet L. A1 Cohen, Ted A1 Colijn, Caroline YR 2013 UL http://stm.sciencemag.org/content/5/204/204lr4.abstract AB Our modeling work suggests that isoniazid preventive therapy (IPT) can be effective in reducing drug-sensitive tuberculosis (TB) and that the risk of IPT driving resistance can be reduced by improving the detection and rapid treatment of individuals with drug-resistant disease and by limiting IPT to those in whom the intervention will have the largest benefit.