RT Journal Article
SR Electronic
T1 Response to Comment on “Community-Wide Isoniazid Preventive Therapy Drives Drug-Resistant Tuberculosis: A Model-Based Analysis”
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP 204lr4
OP 204lr4
DO 10.1126/scitranslmed.3007442
VO 5
IS 204
A1 Mills, Harriet L.
A1 Cohen, Ted
A1 Colijn, Caroline
YR 2013
UL http://stm.sciencemag.org/content/5/204/204lr4.abstract
AB Our modeling work suggests that isoniazid preventive therapy (IPT) can be effective in reducing drug-sensitive tuberculosis (TB) and that the risk of IPT driving resistance can be reduced by improving the detection and rapid treatment of individuals with drug-resistant disease and by limiting IPT to those in whom the intervention will have the largest benefit.