RT Journal Article SR Electronic T1 Genomics in Clinical Practice: Lessons from the Front Lines JF Science Translational Medicine FD American Association for the Advancement of Science SP 194cm5 OP 194cm5 DO 10.1126/scitranslmed.3006468 VO 5 IS 194 A1 Jacob, Howard J. A1 Abrams, Kelly A1 Bick, David P. A1 Brodie, Kent A1 Dimmock, David P. A1 Farrell, Michael A1 Geurts, Jennifer A1 Harris, Jeremy A1 Helbling, Daniel A1 Joers, Barbara J. A1 Kliegman, Robert A1 Kowalski, George A1 Lazar, Jozef A1 Margolis, David A. A1 North, Paula A1 Northup, Jill A1 Roquemore-Goins, Altheia A1 Scharer, Gunter A1 Shimoyama, Mary A1 Strong, Kimberly A1 Taylor, Bradley A1 Tsaih, Shirng-Wern A1 Tschannen, Michael R. A1 Veith, Regan L. A1 Wendt-Andrae, Jaime A1 Wilk, Brandon A1 Worthey, Elizabeth A. YR 2013 UL http://stm.sciencemag.org/content/5/194/194cm5.abstract AB The price of whole-genome and -exome sequencing has fallen to the point where these methods can be applied to clinical medicine. Here, we outline the lessons we have learned in converting a sequencing laboratory designed for research into a fully functional clinical program.