PT  - JOURNAL ARTICLE
AU  - Liauw, Stanley L.
AU  - Connell, Philip P.
AU  - Weichselbaum, Ralph R.
TI  - New Paradigms and Future Challenges in Radiation Oncology: An Update of Biological Targets and Technology
AID  - 10.1126/scitranslmed.3005148
DP  - 2013 Feb 20
TA  - Science Translational Medicine
PG  - 173sr2--173sr2
VI  - 5
IP  - 173
4099  - http://stm.sciencemag.org/content/5/173/173sr2.short
4100  - http://stm.sciencemag.org/content/5/173/173sr2.full
AB  - Radiation oncology exploits the biological interaction of radiation within tissue to promote tumor death while minimizing damage to surrounding normal tissue. The clinical delivery of radiation relies on principles of radiation physics that define how radiation energy is deposited in the body, as well as technology that facilitates accurate tumor targeting. This review will summarize the current landscape of recent biological and technological advances in radiation oncology, describe the challenges that exist, and offer potential avenues for improvement.