RT Journal Article
SR Electronic
T1 CD271<sup>+</sup> Bone Marrow Mesenchymal Stem Cells May Provide a Niche for Dormant <em>Mycobacterium tuberculosis</em>
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP 170ra13
OP 170ra13
DO 10.1126/scitranslmed.3004912
VO 5
IS 170
A1 Das, Bikul
A1 Kashino, Suely S.
A1 Pulu, Ista
A1 Kalita, Deepjyoti
A1 Swami, Vijay
A1 Yeger, Herman
A1 Felsher, Dean W.
A1 Campos-Neto, Antonio
YR 2013
UL http://stm.sciencemag.org/content/5/170/170ra13.abstract
AB Mycobacterium tuberculosis (Mtb) can persist in hostile intracellular microenvironments evading immune cells and drug treatment. However, the protective cellular niches where Mtb persists remain unclear. We report that Mtb may maintain long-term intracellular viability in a human bone marrow (BM)–derived CD271+/CD45− mesenchymal stem cell (BM-MSC) population in vitro. We also report that Mtb resides in an equivalent population of BM-MSCs in a mouse model of dormant tuberculosis infection. Viable Mtb was detected in CD271+/CD45− BM-MSCs isolated from individuals who had successfully completed months of anti-Mtb drug treatment. These results suggest that CD271+ BM-MSCs may provide a long-term protective intracellular niche in the host in which dormant Mtb can reside.