PT  - JOURNAL ARTICLE
AU  - Rosenblum, Michael D.
AU  - Gratz, Iris K.
AU  - Paw, Jonathan S.
AU  - Abbas, Abul K.
TI  - Treating Human Autoimmunity: Current Practice and Future Prospects
AID  - 10.1126/scitranslmed.3003504
DP  - 2012 Mar 14
TA  - Science Translational Medicine
PG  - 125sr1--125sr1
VI  - 4
IP  - 125
4099  - http://stm.sciencemag.org/content/4/125/125sr1.short
4100  - http://stm.sciencemag.org/content/4/125/125sr1.full
AB  - Autoimmune diseases are caused by immune cells attacking the host tissues they are supposed to protect. Recent advances suggest that maintaining a balance of effector and regulatory immune function is critical for avoiding autoimmunity. New therapies, including costimulation blockade, regulatory T cell therapy, antigen-specific immunotherapy, and manipulating the interleukin-2 pathway, attempt to restore this balance. This review discusses these advances as well as the challenges that must be overcome to target these therapies to patients suffering from autoimmune disease while avoiding the pitfalls of general immunosuppression.