RT Journal Article SR Electronic T1 Response to Comments on “The Predictive Capacity of Personal Genome Sequencing” JF Science Translational Medicine FD American Association for the Advancement of Science SP 135lr3 OP 135lr3 DO 10.1126/scitranslmed.3004246 VO 4 IS 135 A1 Vogelstein, Bert A1 Roberts, Nicholas J. A1 Vogelstein, Joshua T. A1 Parmigiani, Giovanni A1 Kinzler, Kenneth W. A1 Velculescu, Victor E. YR 2012 UL http://stm.sciencemag.org/content/4/135/135lr3.abstract AB The power of personal genome sequencing to elucidate disease pathogenesis will ensure that it will become an essential tool in medical practice, but recognizing its limitations for improving public health will minimize false expectations and foster the most fruitful investigations.