RT Journal Article
SR Electronic
T1 Metabolic Syndromes and Malignant Transformation: Where the Twain Shall Meet
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP 54ps50
OP 54ps50
DO 10.1126/scitranslmed.3001669
VO 2
IS 54
A1 Bhagwat, Neha
A1 Levine, Ross L.
YR 2010
UL http://stm.sciencemag.org/content/2/54/54ps50.abstract
AB Recurrent somatic mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes that result in the accumulation of D-2-hydroxyglutarate (D-2-HG) have been identified in malignant gliomas and in acute myeloid leukemia (AML). However, the function of this metabolite in normal and malignant tissues remains uncertain. A report in the current issue of Science describes a germline IDH2 mutation in a subset of patients with a rare metabolic disorder—D-2-hydroxyglutaric aciduria—that is similar to mutations seen in cancer patients. These observations further elucidate the effects of IDH mutations on normal and malignant cells.