PT  - JOURNAL ARTICLE
AU  - Bhagwat, Neha
AU  - Levine, Ross L.
TI  - Metabolic Syndromes and Malignant Transformation: Where the Twain Shall Meet
AID  - 10.1126/scitranslmed.3001669
DP  - 2010 Oct 20
TA  - Science Translational Medicine
PG  - 54ps50--54ps50
VI  - 2
IP  - 54
4099  - http://stm.sciencemag.org/content/2/54/54ps50.short
4100  - http://stm.sciencemag.org/content/2/54/54ps50.full
AB  - Recurrent somatic mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes that result in the accumulation of D-2-hydroxyglutarate (D-2-HG) have been identified in malignant gliomas and in acute myeloid leukemia (AML). However, the function of this metabolite in normal and malignant tissues remains uncertain. A report in the current issue of Science describes a germline IDH2 mutation in a subset of patients with a rare metabolic disorder—D-2-hydroxyglutaric aciduria—that is similar to mutations seen in cancer patients. These observations further elucidate the effects of IDH mutations on normal and malignant cells.