RT Journal Article
SR Electronic
T1 H1N1: Can a Pandemic Cycle Be Broken?
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP 24ps14
OP 24ps14
DO 10.1126/scitranslmed.3000948
VO 2
IS 24
A1 Settembre, Ethan C.
A1 Dormitzer, Philip R.
A1 Rappuoli, Rino
YR 2010
UL http://stm.sciencemag.org/content/2/24/24ps14.abstract
AB The influenza virus that caused the 2009 H1N1 swine-origin flu pandemic is antigenically similar to the one that caused the devastating 1918 pandemic. Over time, the human population became susceptible to a modified version of the 1918 pandemic H1N1 virus that had been archived in swine. Now, two papers, one in this issue of Science Translational Medicine and one in Science, shed mechanistic light on how glycosylation gave rise to seasonal human flu viruses that are immunologically distinct from their 1918 pandemic precursor and the 2009 pandemic strain. These findings suggest strategies to anticipate and prevent future pandemics. Copyright © 2010, American Association for the Advancement of Science