PT - JOURNAL ARTICLE AU - Garraway, Levi A. AU - Hahn, William C. TI - On or Off Target: Mutations, Models, and Predictions AID - 10.1126/scitranslmed.3001263 DP - 2010 Jun 09 TA - Science Translational Medicine PG - 35ps28--35ps28 VI - 2 IP - 35 4099 - http://stm.sciencemag.org/content/2/35/35ps28.short 4100 - http://stm.sciencemag.org/content/2/35/35ps28.full AB - In a series of articles published in February 2010, The New York Times chronicled, from a personal perspective, the rollercoaster experience of those associated with clinical trials of a RAF inhibitor for the treatment of melanoma. In this issue of Science Translational Medicine, Whittaker et al. describe research that reconciles some of the bewildering aspects of the discovery and development of drugs that inhibit such protein kinase targets in cancer. Copyright © 2010, American Association for the Advancement of Science