PT  - JOURNAL ARTICLE
AU  - Garraway, Levi A.
AU  - Hahn, William C.
TI  - On or Off Target: Mutations, Models, and Predictions
AID  - 10.1126/scitranslmed.3001263
DP  - 2010 Jun 09
TA  - Science Translational Medicine
PG  - 35ps28--35ps28
VI  - 2
IP  - 35
4099  - http://stm.sciencemag.org/content/2/35/35ps28.short
4100  - http://stm.sciencemag.org/content/2/35/35ps28.full
AB  - In a series of articles published in February 2010, The New York Times chronicled, from a personal perspective, the rollercoaster experience of those associated with clinical trials of a RAF inhibitor for the treatment of melanoma. In this issue of Science Translational Medicine, Whittaker et al. describe research that reconciles some of the bewildering aspects of the discovery and development of drugs that inhibit such protein kinase targets in cancer. Copyright © 2010, American Association for the Advancement of Science