RT Journal Article SR Electronic T1 Thinking Outside the Box: Fostering Innovation and Non–Hypothesis-Driven Research at NIH JF Science Translational Medicine FD American Association for the Advancement of Science SP 70cm5 OP 70cm5 DO 10.1126/scitranslmed.3001742 VO 3 IS 70 A1 Aragon, Richard YR 2011 UL http://stm.sciencemag.org/content/3/70/70cm5.abstract AB The National Institutes of Health (NIH) has long been known as an institution that supports biomedical advances through hypothesis-driven research. Another aspect of NIH, however, has received comparatively little attention and may be critical to advancing translational science beyond its current limitations. Specifically, this aspect of NIH focuses on supporting innovation through the development of high-risk technologies that have the potential to empower research.