PT  - JOURNAL ARTICLE
AU  - Wu, Chin-Lee
AU  - Jordan, Kate W.
AU  - Ratai, Eva M.
AU  - Sheng, Jinhua
AU  - Adkins, Christen B.
AU  - DeFeo, Elita M.
AU  - Jenkins, Bruce G.
AU  - Ying, Leslie
AU  - McDougal, W. Scott
AU  - Cheng, Leo L.
TI  - Metabolomic Imaging for Human Prostate Cancer Detection
AID  - 10.1126/scitranslmed.3000513
DP  - 2010 Jan 27
TA  - Science Translational Medicine
PG  - 16ra8--16ra8
VI  - 2
IP  - 16
4099  - http://stm.sciencemag.org/content/2/16/16ra8.short
4100  - http://stm.sciencemag.org/content/2/16/16ra8.full
AB  - As current radiological approaches cannot accurately localize prostate cancer in vivo, biopsies are conducted at random within prostates for patients at risk for prostate cancer, leading to high false-negative rates. Metabolomic imaging can map cancer-specific biomolecular profile values onto anatomical structures to direct biopsy. In this preliminary study, we evaluated five whole prostates removed during prostatectomy from biopsy-proven cancer patients on a 7-tesla human whole-body magnetic resonance scanner. Localized, multi–cross-sectional, multivoxel magnetic resonance spectra were used to construct a malignancy index based on prostate cancer metabolomic profiles obtained from previous intact tissue analyses with a 14-tesla spectrometer. This calculated malignancy index is linearly correlated with lesion size and demonstrates a 93 to 97% overall accuracy for detecting the presence of prostate cancer lesions, suggesting the potential clinical utility of this approach. Copyright © 2010, American Association for the Advancement of Science