Supplementary Materials

The PDF file includes:

  • Materials and Methods.
  • Fig. S1. General symptoms and infected cell types in olfactory mucosa of patients with COVID-19 at the acute phase.
  • Fig. S2. Experimental design of the experiments and complementary behavioral tests with golden hamsters.
  • Fig. S3. SARS-CoV-2 induces loss of ciliation in the golden hamster olfactory epithelium.
  • Fig. S4. Cell types infected by SARS-CoV-2 in hamster olfactory mucosa and subsequent cell death.
  • Fig. S5. Clinical and virologic profiles from patients with persistent olfactory dysfunction post-COVID-19 compared to patients with COVID-19 exhibiting loss of smell at early onset and controls.
  • Table S1. Features at inclusion of the participants with recent loss of smell associated to COVID-19.
  • Table S2. SARS-CoV-2 titer in the olfactory mucosa in two patients with recent loss of smell associated to COVID-19.
  • Table S3. Characteristics of smell and taste abnormalities at inclusion of the participants with recent loss of smell associated to COVID-19.
  • Table S4. Individual features at inclusion of the participants with persistent olfactory dysfunction.
  • Table S5. Characteristics of smell and taste abnormalities at inclusion of the participants with persistent olfactory dysfunction.
  • Table S6. Primer sequences used for qPCR in the golden hamster tissues.

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1. Raw data except RNA-seq (provided as supplementary Excel file).
  • Data file S2. Raw data for RNA-seq/Fig. 7 (provided as supplementary Excel file).