Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Glucose metabolic parameters of NS mice.
  • Fig. S2. Metabolic parameters of NS mice and response to HFD.
  • Fig. S3. The glucose intolerance is transferred with hematopoietic cells.
  • Fig. S4. Hyperactive SHP2 mutation affects macrophage behavior.
  • Fig. S5. Effect of SHP099 treatment on HFD B6x129Sv genetic background mice.
  • Fig. S6. Comparison between SHP099, rosiglitazone, and metformin on the metabolic profile of HFD mice.
  • Table S1. Genetic confirmation of patients with NS.
  • Table S2. Metabolic parameters of patients with NS and lean, normal-weight, and obese individuals.
  • Table S3. Primer sequences.
  • Legend for data file S1
  • References (5459)

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Other Supplementary Material for this manuscript includes the following: