Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Recombinant expression, biophysical characterization, and binding kinetics.
  • Fig. S2. Epitope binning heat map.
  • Fig. S3. Biolayer interferometry measurements of Fab-spike binding kinetics.
  • Fig. S4. Epitope binning communities for 24 selected antibodies.
  • Fig. S5. Structural assessment of antibody epitopes.
  • Fig. S6. Cryo-EM structure validation.
  • Fig. S7. Timeline, screening, and sequence analysis.
  • Table S1. Epitope binding domains and affinities.
  • Table S2. Selected mAb information.
  • Table S3. Hydrogen/deuterium exchange data summary.
  • Table S4. Summary of viral neutralization data.
  • Table S5. Gross pathology findings.
  • Table S6. Statistical analyses for impact of LY-CoV555 on viral loads in SARS-CoV-2-challenged rhesus macaques.
  • Table S7. Serum human IgG concentrations and AUC0-6days following IV administration of LY-CoV555 or Control IgG to rhesus macaques before and during SARS-CoV-2 challenge.
  • Table S8. BALF and estimated ELF fluid concentrations following IV administration of LY-CoV555 or Control IgG to rhesus macaques during SARS-CoV-2 challenge.
  • Table S9. Cryo-Electron Microscopy data collection and refinement statistics.
  • Table S10. Crystallographic statistics.

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Other Supplementary Material for this manuscript includes the following: