Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Proteomics heatmap.
  • Fig. S2. Durability testing of the tri-tube valve.
  • Fig. S3. Gen 1 valve performance in pulse duplicator system.
  • Fig. S4. Epicardial echocardiographic images at implantation.
  • Fig. S5. Kaplan-Meier survival curves.
  • Fig. S6. Stress-strain curves.
  • Fig. S7. ANSYS valve models.
  • Table S1. Proteomics protein quantification.
  • Table S2. Summary of pulse duplicator testing of bovine, porcine, and Gen 1 valves.
  • Table S3. Summary of echocardiography for Gen 1 and Gen 2 valves 1 week after implantation.
  • Legends for data files S1 to S4
  • Legends for movies S1 to S10
  • References (2836)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Suture pullout force testing.
  • Data file S2 (Microsoft Excel format). Leaflet coaptation and free-edge length measurements from echocardiographic images.
  • Data file S3 (Microsoft Excel format). Ki67 staining and DNA measurements of 12- and 20-week explanted Gen 1 valves.
  • Data file S4 (Microsoft Excel format). Calcium concentration preimplant and explant measurements.
  • Movie S1 (.mp4 format). End-on view of 19-mm Gen 1 tri-tube valved conduit during hydrodynamic testing.
  • Movie S2 (.mp4 format). End-on view of 20-mm bovine valve during hydrodynamic testing.
  • Movie S3 (.mp4 format). End-on view of 18-mm porcine valve during hydrodynamic testing.
  • Movie S4 (.mp4 format). Transthoracic echocardiography of Gen 1 valves 1-week post-operation.
  • Movie S5 (.mov format). Transthoracic echocardiography of the 36-week explant Gen 1 valve at 28 weeks post-operation (PACV 3).
  • Movie S6 (.mov format). Transthoracic echocardiography of the 62-week explant Gen 1 valve at 52 weeks post-operation (PACV 4).
  • Movie S7 (.mov format). Transthoracic echocardiography of Gen 2 valves 1-week post-operation.
  • Movie S8 (.mov format). Transthoracic echocardiography of first 52-week explant Gen 2 valve at 52 weeks post-operation (PACV 5).
  • Movie S9 (.mov format). Transthoracic echocardiography of second 52-week explant Gen 2 valve at 52 weeks post-operation (PACV 6).
  • Movie S10 (.mov format). Transthoracic echocardiography of third 52-week explant Gen 2 valve at 52 weeks post-operation (PACV 7).