Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Expression of SARS-CoV-2 entry factors in iPSC-derived cardiac cells, productive infection assay and drug pretreatment effects.
  • Fig. S2. Transcriptional disruption and cellular pathway dysregulation due to SARS-CoV-2 exposure in cardiac cells.
  • Fig. S3. Heat maps for gene pathways of interest, comparing transcriptional differences in mock and SARS-CoV-2-infected cardiomyocytes.
  • Fig. S4. Cardiomyocyte infection by SARS-CoV-2 leads to dramatic transcriptomic disruption in genes related with the nuclear envelope and sarcomere structures.
  • Fig. S5. iPSC-CM cultures infected with SARS-CoV-2 display myofibrillar fragmentation.
  • Fig. S6. Myofibrillar fragmentation phenotype is partially recapitulated by proteasomal inhibition, but not by cardiotoxic drug doxorubicin or infection by coronavirus NL-63 or OC-43.
  • Fig. S7. Additional representative images from heart autopsy samples from patients with and without COVID-19.
  • Table S1. List of reagents.
  • Table S2. List of dyes, primary and secondary antibodies used for immunocytochemistry and paraffin sections.
  • Table S3. List of RT-qPCR primer and probe sequences.
  • References (7584)

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Other Supplementary Material for this manuscript includes the following: