Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Chi-Adu treatment reduces amyloid burden in a mouse model of parenchymal Aβ plaques.
  • Fig. S2. HAE-4 strongly reduces Aβ parenchymal plaques of varying sizes in 5XE4 mice.
  • Fig. S3. No sex-dependent effect of HAE-4 or chi-Adu on Aβ plaque pathology or microhemorrhages.
  • Fig. S4. Mean baseline vessel diameter and CAA coverage are consistent between treatment groups.
  • Fig. S5. Endothelial markers are initially up-regulated but become quiescent with plaque removal after HAE-4 treatment.
  • Fig. S6. Acute HAE-4 and chi-Adu treatments promote bidirectional glial clustering around Aβ plaques.
  • Fig. S7. Schematic summary of differential HAE-4 and chi-Adu antibody effects in a mouse model with robust CAA.
  • Table. S1. Demographics of human brain tissue.
  • Table. S2. No difference in blood gas measurements at baseline and hypercapnia.
  • Legend for data file S1
  • References (50, 51)

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Other Supplementary Material for this manuscript includes the following: