Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Characterization of concentration-dependent LATTE diffusion in the rat liver.
  • Fig. S2. Ex vivo microCT scans of the N1S1 liver tumor after treatment with saline, EtOH, or LATTE.
  • Fig. S3. Effect of intratumoral injection of LATTE on recruitment of macrophages and T lymphocytes.
  • Fig. S4. Time-dependent evaluation of drug diffusion and retention after LATTE injection into the rat liver.
  • Fig. S5. The cytotoxic effect of combined LATTE and Dox on HepG2 cells.
  • Fig. S6. Effect of LATTE treatment on PANC-1 and SNU-478 cancer cell viability.
  • Fig. S7. Image-guided injection of LATTE into the pig liver.
  • Fig. S8. NIRF imaging and histological evaluation of explanted human tumors after injection with LATTE.
  • Fig. S9. NIRF imaging and histological evaluation of explanted human renal cancer tumors after injection with LATTE.
  • Table S1. Serum blood chemistry in rats with N2S1 tumors receiving intratumor injection of saline, EtOH, or LATTE.
  • Legend for data file S1
  • Legend for movie S1
  • References (5156)

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Individual subject-level data.
  • Movie S1 (.mp4 format). Image-guided injection of LATTE into the rabbit VX2 liver tumor.