Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Histomorphometric changes in DMM mice during the time course of OA development.
  • Fig. S2. Short-term chondrocyte-specific GRK2 deletion recovers Gαs signaling in DMM mice.
  • Fig. S3. Inducible conditional GRK2 deletion in sham-operated knees promotes their chondrocyte anabolic activity.
  • Fig. S4. Paroxetine and inducible conditional GRK2 deletion have effects on the fibrocartilage structure.
  • Fig. S5. Short-term pharmacologic GRK2 inhibition recovers Gαs signaling in DMM mice.
  • Fig. S6. Effect of paroxetine on serotonin transporter and serotonin receptor 2C expression in the articular cartilage of DMM mice.
  • Fig. S7. Serotonin receptor expression in articular cartilage of sham and DMM mice.
  • Fig. S8. Paroxetine treatment does not provide additive chondroprotective or matrix-regenerative effects when combined with conditional GRK2 deletion in DMM mice.
  • Fig. S9. Lack of effect of paroxetine on trabecular bone in DMM mice.
  • Fig. S10. GRK2 inhibition as a therapeutic approach for OA.
  • Table S1. List of the primary antibodies used for IF staining.
  • Table S2. List of the gene expression assays used for RT-qPCR.
  • References (7584)

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Individual subject-level data for n < 20.