Supplementary Materials

The PDF file includes:

  • Fig. S1. Morphine-induced itch, hyperknesis, and alloknesis in obstetric patients.
  • Fig. S2. Morphine-induced itch, hyperknesis, and alloknesis in mice.
  • Fig. S3. Differential role of mast cells on subcutaneous versus intrathecal morphine–induced itch.
  • Fig. S4. Spinal expression of Oprm1 in Grpr, Pdyn, and Npy neurons.
  • Fig. S5. Expression of Oprm1 in Npy neurons is not required for morphine-induced itch.
  • Fig. S6. Validation of viral infection of Pdyn+ neurons.
  • Fig. S7. Dose-response analysis of nalfurafine treatment for morphine-induced itch.
  • Fig. S8. Antagonism of the kappa-opioid receptor evokes itch.
  • Legend for data file S1

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Individual-level data in tabular format.