Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. GWAS and eQTL studies at the chromosome 4 CKD locus.
  • Fig. S2. Genotype and gene expression association of NFKB1.
  • Fig. S3. Genotype and gene expression association in human kidney tubules and glomeruli.
  • Fig. S4. Genotype and gene expression association in the NephQTL database.
  • Fig. S5. Genotype and gene expression association in the GTEx database.
  • Fig.S6. Genotype-gene expression correlation in multiple human tissue samples.
  • Fig.S7. Kidney tubule chromatin conformation capture map.
  • Fig.S8. PheWAS of subjects with heterozygous LoF MANBA variants.
  • Fig. S9. Characterization of Manba−/− mice.
  • Fig. S10. Sirius red staining of wild-type and Manba−/− mice after cisplatin injection.
  • Fig. S11. Genetic loss of Manba associated with reduced autophagosome biogenesis.
  • Fig. S12. Genetic loss of Manba impairs autophagic flux.
  • Fig. S13. MANBA expression in the human kidney.
  • Table S1. Renal phenotype association of MANBA heterozygous LoF variants in PMBB and BioMe.
  • Table S2. Top 50 differentially expressed genes identified in heterozygous versus reference at SNP 6847587.
  • Table S3. Sequences of oligonucleotide primers used for qPCR.

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Other Supplementary Material for this manuscript includes the following: