Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. A genome-wide CRISPR-Cas9–based screen for senescence-promoting genes in hMPCs.
  • Fig. S2. KAT7 knockdown reverses the premature aging phenotypes of WS hMPCs.
  • Fig. S3. KAT7 regulates both physiological and pathological cellular aging.
  • Fig. S4. KAT7 regulates cellular senescence induced by different stressors.
  • Fig. S5. KAT7 promotes cellular senescence in early-passage hMPCs.
  • Fig. S6. KAT7 regulates cellular senescence via acetylation of H3K14 and subsequent upregulation of p15INK4b.
  • Fig. S7. p15INK4b regulates cellular senescence in hMPCs.
  • Fig. S8. Expression of KAT7 and p15INK4b increases with age.
  • Fig. S9. KAT7 regulates individual life span in mice.
  • Fig. S10. Knockout of KAT7 alleviates hepatocyte senescence.
  • Legends for data files S1 to S3

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1. TOP 100 ranked genes in the genome-wide CRISPR-based screen and DEGs of RNA-seq (Excel).
  • Data file S2. Primer and antibody information as well as donor information (Excel).
  • Data file S3. Raw data (Excel).