Supplementary Materials

The PDF file includes:

• Fig. S1. Age, duration of symptoms, and sex do not correlate with plasma IgA or IgG neutralization ability.
• Fig. S2. Analysis of antibody somatic hypermutation.
• Fig. S3. Analysis of antibody CDR3 length.
• Fig. S4. Analysis of antibody CDR3 hydrophobicity.
• Fig. S5. Frequency distributions of human V genes.
• Fig. S6. Binding and neutralizing activity of anti-SARS-CoV-2 RBD IgA and IgM monomers.
• Fig. S7. Biolayer interferometry experiment.
• Fig. S8. Purification of Dimeric IgA by Size Exclusion Chromatography.
• Fig. S9. Neutralizing activity of monoclonal monomeric and dimeric IgA antibodies.
• Table S1. Inhibitory concentrations of monoclonal antibodies from isotype shared clones.
• Table S2. Inhibitory concentrations of monoclonal IgA monomers and dimers.

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Other Supplementary Material for this manuscript includes the following:

• Data File S1. Sequences of anti-SARS-CoV-2 antibodies.
• Data File S2. Sequences of antibodies from isotype shared clones.
• Data File S3. Sequences of cloned recombinant antibodies.
• Data File S4. Effective and inhibitory concentrations of monoclonal antibodies.
• Data File S5. Primers.
• Data File S6. Raw data for graphs with n < 20.