Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Artifacts from stimulation impaired data collection from VIM contacts.
  • Fig. S2. Artifacts from stimulation did not impair movement detection performances from cortical contacts.
  • Fig. S3. Implementation of CL-DBS in a patient affected by ET showing spectral leakage of the stimulation artifact.
  • Fig. S4. Performances of the embedded detector over the monthly clinical/research visit in all the enrolled subjects.
  • Fig. S5. TRS improvements versus TEED savings in percent.
  • Fig. S6. Energy performance of CL-DBS at monthly visits in all the enrolled subjects compared to OL-DBS energy consumption (TEED).
  • Fig. S7. PSD and impedance over a 6-month period.
  • Fig. S8. Performance of CL-DBS in patients affected by ET during speech execution.
  • Fig. S9. Example of a non-optimized embedded closed-loop stimulation paradigm.
  • Fig. S10. Stimulation delivery estimated by two different methodologies.
  • Table S1. Subject demographics for the study.
  • Table S2. DBS and closed-loop settings at each month for each patient during TRS clinical evaluation.
  • Table S3. DBS-related side effects and preference reported.
  • Legends for movies S1 to S3
  • Legends for data files S1 and S2
  • References (7180)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). Comparison between DBS OFF, CL-DBS (fully embedded implementation), and OL-DBS in ET01 during a volitional movement task.
  • Movie S2 (.mp4 format). Comparison between DBS OFF, CL-DBS (fully embedded implementation), and OL-DBS in ET02 during a cued-go cup reaching task.
  • Movie S3 (.mp4 format). Comparison between DBS OFF, CL-DBS (fully embedded implementation), and OL-DBS in ET03 during a volitional cup reaching task.
  • Data file S1. Data for Figs. 2 to 6 and figs. S3, S4, and S6 (provided as separate Excel file).
  • Data file S2. Data for figs. S1, S2, S5, and S7 to S10 (provided as separate Excel file).