Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Measurement of food and water consumption during sugar treatment.
  • Fig. S2. HGD exacerbates DSS-induced colitis.
  • Fig. S3. Dietary simple sugars enhance colitis pathogenesis.
  • Fig. S4. Effect of pre-DSS sugar treatment on colitis.
  • Fig. S5. High glucose triggers induction of inflammatory cytokines in Il10−/− mouse colons.
  • Fig. S6. The effect of glucose and fructose on gut physiology of healthy WT mice.
  • Fig. S7. The effect of glucose on gut physiology of healthy Il10−/− mice.
  • Fig. S8. The impact of high fructose and sucrose on gut microbiota composition.
  • Fig. S9. High-sugar diet shifts gut microbiota composition.
  • Fig. S10. Microbial species most abundantly affected by high-fructose and high-sucrose diet.
  • Fig. S11. HGD leads to degradation of mucus layer.
  • Fig. S12. Colitis in Il10−/− is promoted with glucose consumption.
  • Fig. S13. The effect of antibiotic treatment on water consumption and bacterial load in the gut.
  • Fig. S14. Transplantation of glucose-treated fecal microbiota induces increased inflammation in recipient mice.
  • Table S1. Primer sequences for the measurement of gene expression by real-time qPCR.
  • Table S2. Primers used in real-time qPCR analysis of bacterial 16S rRNA genes.
  • Legends for data files S1and S2
  • References (58, 59)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 Primary data of main figures (provided as separate Excel file).
  • Data file S2 Primary data of supplementary figures (provided as separate Excel file).