Supplementary Materials

The PDF file includes:

  • Fig. S1. Injected versus noninjected lesions.
  • Fig. S2. Multiplex immunofluorescence staining.
  • Fig. S3. Changes in apoptosis, necrosis, PD-L1, and CD8 and CD4 immunostaining after BO-112.
  • Fig. S4. Heatmaps of gene expression in cohorts 1 to 3.
  • Fig. S5. Unsupervised clustering of expression data in cohort 4.
  • Table S1. PFS pre- and post-study in patients experiencing PD.
  • Table S2. IHC findings.
  • Table S3. Adjusted gene expression analysis for cohorts 1 to 3.
  • Table S4. Gene expression analysis for BO-112 signature.

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (.pdf format). Study protocol version 7.0.
  • Data file S2 (Microsoft Excel format). Gene expression raw data.