Supplementary Materials

The PDF file includes:

  • Fig. S1. Neonatal infection leads to persistent infection.
  • Fig. S2. Parasite persistence leads to impaired growth and weight gain.
  • Fig. S3. Enhanced bile secretion upon G. lamblia persistence.
  • Fig. S4. Bile-derived LysoPC as a metabolic substrate and persistence-promoting factor for G. lamblia.
  • Fig. S5. Infection-induced changes of the enteric microbiota.
  • Fig. S6. Metabolic consequences of persistent G. lamblia infection.
  • Fig. S7. G. lamblia infection of adult germ-free animals.
  • Fig. S8. Potential mechanisms contributing to reduced postnatal body weight gain and linear growth.
  • Table S1. Metabolic profiling for acylcarnitines in serum of mice persistently infected with G. lamblia versus healthy age-matched control animals.
  • Table S2. Metabolic profiling for PCs in total liver tissue of mice persistently infected with G. lamblia versus healthy age-matched control animals.
  • Table S3. Bile acid standards for metabolically profiling bile acids.

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). Representative live imaging of a healthy 4-week-old mouse.
  • Movie S2 (.mp4 format). Representative live imaging of a mouse, infected at the age of 3 days with G. lamblia, at 4 weeks p.i.
  • Data file S1 (Microsoft Excel format). Individual-level data for all figures.