Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Each population of hiPSC-CCs was >94% pure.
  • Fig. S2. Exosomes from hiPSC-CCs were taken up by cultured hiPSC-CMs.
  • Fig. S3. hiPSC-CM apoptosis is negligible under normoxic conditions.
  • Fig. S4. hiPSC-CC exosomes up-regulate the expression of HIF-1α in hiPSC-CMs under hypoxic conditions.
  • Fig. S5. hiPSC-CC exosomes promote hiPSC-CM proliferation.
  • Fig. S6. Mimics of miRNAs from hiPSC-CC exosomes increase angiogenic activity in ECs and protect hiPSC-CMs from hypoxia.
  • Fig. S7. hiPSC-CCs engraft and survive after transplantation into infarcted swine hearts.
  • Fig. S8. Antibody specificity.
  • Fig. S9. hiPSC-CCs and hiPSC-CC exosomes enhance myocardial mitotic activity after administration to infarcted swine hearts.
  • Table S1. Number of animals evaluated per experimental group.
  • Table S2. Ventricular arrhythmia inducibility by PES.
  • Table S3. Antibodies.

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Individual subject-level data.