Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Poly(GR) accelerates and enhances TDP-43 aggregation.
  • Fig. S2. Poly(GR) mediates sequestration of cytosolic full-length TDP-43 into the inclusions.
  • Fig. S3. TDP-43 and DPR burden in mouse and human.
  • Fig. S4. Poly(GR) aggregates sequester nuclear pore POM121 protein in vivo.
  • Fig. S5. c9ASO reduces G4C2 repeat–containing RNA and sense DPR protein burden.
  • Table S1. cDNA sequence of the GFP-(GR)200 and mCherry-(GR)100 plasmids.
  • Table S2. Primary antibodies for Western blot, immunohistochemistry, and immunofluorescence staining.
  • Table S3. Characteristics of patients with c9FTD/ALS.
  • Table S4. Primers for qPCR.
  • Legend for Data file S1
  • References (48, 49)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Raw data for all the quantitative figures where n < 20.