Supplementary Materials

The PDF file includes:

  • Fig. S1. Agrin is up-regulated by inflammation and its silencing does not affect the expression of DKK1.
  • Fig. S2. Activation of WNT signaling by disruption of the β-catenin destruction complex does not affect the chondrogenic effect of agrin.
  • Fig. S3. Agrin induces CREB phosphorylation.
  • Fig. S4. Model of osteochondral injury.
  • Fig. S5. Agrin fails to up-regulate GDF5 in bone marrow stromal cells.
  • Fig. S6. Activity of a recombinant agrin deletion mutant.
  • Table S1. Ages of operated sheep.
  • Table S2. Antibody supplier and usage information.
  • Table S3. Recombinant proteins and reagents supplier and usage information.
  • Table S4. Primer and siRNA sequences.
  • R script for download and statistical analysis of microarray data from Comblain et al. (29)

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Other Supplementary Material for this manuscript includes the following: