Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. In vitro characterization of HUMBLE cells.
  • Fig. S2. Metabolic characterization of mice transplanted with HUMBLE preadipocytes.
  • Fig. S3. Metabolic characterization of mice transplanted with HUMBLE cells engineered from white preadipocytes in a different individual.
  • Fig. S4. Metabolic characterization of mice transplanted with differentiated HUMBLE adipocytes.
  • Fig. S5. Effects on BAT, scWAT, and muscle in mice after transplantation of HUMBLE cells.
  • Fig. S6. Arginine metabolism in HUMBLE adipocytes.
  • Fig. S7. HUMBLE cells activate NO-mediated pathway in endogenous murine BAT.
  • Fig. S8. Metabolic characterization of mice transplanted with eNOS KO HUMBLE cells.
  • Fig. S9. Metabolic characterization of mice transplanted with white control cells overexpressing eNOS.
  • Table S1. sgRNAs targeting the human UCP1 promoter.
  • Table S2. Primer sequences.
  • Table S3. Antibodies.
  • Legend for data file S1
  • References (6368)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Individual-level data for all figures.