Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Male and female hAPP mouse mortality on a mixed genetic background.
  • Fig. S2. Human and mouse gonadal hormones in aging.
  • Fig. S3. Swim speeds and visible platform performance of mice in a water maze test.
  • Fig. S4. Male sex and cognitive deficits under several conditions.
  • Fig. S5. Male sex worsens cognition in another transgenic hAPP line.
  • Fig. S6. Aβ and related proteins in XX- and XY-hAPP mice crossed with FCG and XY* models.
  • Fig. S7. Western blot image of hAPP, t-Tau, p-Tau, and loading controls.
  • Fig. S8. 3D6 immunostaining specificity for Aβ plaques.
  • Fig. S9. Aβ plaque area in very old female hAPP mice.
  • Fig. S10. hAPP mRNA expression with and without gonadectomy.
  • Fig. S11. Independent, replicate water maze cohort of FCG mice crossed with hAPP mice.
  • Fig. S12. Sex chromosomes and fear memory impairment in male hAPP mice.
  • Fig. S13. KDM6A variant, other clinical exam scores, and assessment of women only.
  • Fig. S14. Cell death induced by Aβ toxicity and assessed by LDH release assay.
  • Fig. S15. Kdm6a overexpression and other behavioral tasks in male XY-hAPP mice.
  • Table S1. KDM6A in AD and control brain tissues.
  • Table S2. GSE 15222 cohort characteristics.
  • Table S3. Mayo and Mount Sinai Brain Bank sample characteristics.
  • Table S4. ADNI cohort characteristics.
  • Table S5. Longitudinal and subgroup analyses in the ADNI cohort.
  • References (108134)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Primary data for figures.