Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Figure S1. X-ray cocrystal structures of compounds with coronavirus 3CLpro showing the Fo-Fc omit map.
  • Figure S2: X-ray cocrystal structures of compounds with coronavirus 3CLpro showing hydrogen bond interactions.
  • Figure S3: X-ray cocrystal structures of compounds with coronavirus 3CLpro showing electrostatic surface representation.
  • Figure S4: X-ray cocrystal structures of comparative binding of 7j with the 3CLpro of MERS CoV, SARS-CoV and SARS-CoV-2.
  • Table S1: Compound IC50 in the FRET enzyme assay and CC50 in a cell culture assay for MERS-CoV 3CLpro
  • Table S2: Cocrystal structure data for compounds with the 3CLpro of MERS CoV and SARS CoV.
  • References (51�56)

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Other Supplementary Material for this manuscript includes the following: