Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Proteomic analysis of mouse ADPKD kidneys.
  • Fig. S2. Immunoblot analysis of NRF2 in cytosol and nuclear fraction of WT and Pkd1−/− mouse kidneys.
  • Fig. S3. Loss of Nrf2 increases oxidative stress and accelerates cystogenesis in ADPKD mouse model.
  • Fig. S4. SFN treatment inhibits cystogenesis in ADPKD mouse models.
  • Fig. S5. TDZD-8 treatment increases the expression of NRF2 targets and improves kidney function in ADPKD mice.
  • Fig. S6. SFN treatment increases the expression of NRF2 targets and promotes enhancer activation.
  • Fig. S7. NRF2 forms liquid droplets in vitro.
  • Table S1. Demographic and clinical information of patients.
  • Table S2. Single-guide RNA sequences used to knock out NRF2 by CRISPR/Cas-9 gene editing.
  • Legend for data file S1

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1. Individual subject-level data (Microsoft Excel file).