Supplementary Materials

The PDF file includes:

• Materials and Methods
• Fig. S1. Univariate humoral immune response comparisons across MAL068 vaccinees.
• Fig. S2. Model performance in RRR vaccinees.
• Fig. S3. Different concentrations of CSP-specific antibodies track with protection within arms.
• Fig. S4. Model performance in ARR vaccinees.
• Fig. S5. Performance of model separating protected from infected vaccinees, independent of vaccine arm in the MAL068 study.
• Fig. S6. Measurement of antibody concentrations alone cannot predict protection in the MAL068 study.
• Fig. S7. Measurement of hepatitis B virus–specific antibody concentrations cannot predict protection in the MAL068 study.
• Fig. S8. Architecture of immune responses in individuals vaccinated with RTS,S/AS01 across studies.
• Fig. S9. In vitro and in vivo activity of CSP-specific monoclonal antibodies.
• References (69–91)

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Other Supplementary Material for this manuscript includes the following:

• Data file S1 (Microsoft Excel format). Primary data.
• Data file S2 (.zip format). Analysis code.