Supplementary Materials

The PDF file includes:

  • Fig. S1. Synthesis of MIPS-19416.
  • Fig. S2. Raw aggregation data used to generate the concentration-response curves for inhibition by MIPS-21335, MIPS-19416, and copanlisib.
  • Fig. S3. Concentration-inhibition curves for MIPS-21335, MIPS-19416, and copanlisib.
  • Fig. S4. MIPS-19416 treatment does not increase platelet membrane reserves.
  • Fig. S5. MIPS-19416 treatment does not impair platelet tether-dependent adhesion to vWF.
  • Fig. S6. MIPS-19416 does not affect the platelet microtubule ring or filamentous actin formation.

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). Vehicle-treated human platelet 3D reconstruction via FIB-SEM.
  • Movie S2 (.mov format). MIPS-19416-treated human platelet 3D reconstruction via FIB-SEM.