Supplementary Materials

The PDF file includes:

• Figure S1: Purified SARS-CoV-2 proteins analyzed by SDS-PAGE under reducing and non-reducing conditions.
• Figure S2: Anti-spike reactivity of post-vaccination rabbit sera measured by ELISA.
• Figure S3: Isotyping of rabbit serum binding to the SARS-CoV-2 spike protein following immunization.
• Figure S4: Steady-state equilibrium analysis of serum antibody binding by SPR.
• Figure S5: Neutralizing activity of post-vaccination rabbit serum antibodies in a pseudovirion neutralization assay.
• Figure S6. Sequence alignment of spike protein from diverse CoV strains.
• Figure S7. Structural representation of antigenic sites identified in SARS-CoV-2 using GFDPL.
• Table S1. Sequence conservation of antigenic sites among different CoV strains

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Other Supplementary Material for this manuscript includes the following:

• Data file S1 Primary data