Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. SPINK7 inhibits KLK5 and KLK12.
  • Fig. S2. Generation of Klk5-deficient mice.
  • Fig. S3. A1AT inhibits KLK5 in vitro and trypsin-like proteolytic activity and CCL11 production in vivo.
  • Fig. S4. SPINK5 inhibits KLK5 in vitro.
  • Fig. S5. Esophageal KLK and F2RL1 expression profile.
  • Fig. S6. CCL11 production in the esophagus.
  • Fig. S7. A model of the SPINK7, KLK5, and PAR2 pathway in EoE.
  • Table S1. Prevalence rate of A1AD in patients with EoE compared to the general population.
  • Table S2. List of bacteria at the family level that are differentially abundant in the esophagus of Klk5-deficient mice.
  • Legend for table S3
  • Legend for data file S1
  • References (6783)

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Other Supplementary Material for this manuscript includes the following:

  • Table S3 (Microsoft Excel format). List of the most enriched genes in epithelial clusters 1, 2, and 3.
  • Data file S1 (Microsoft Excel format). Primary data.