Supplementary Materials

This PDF file includes:

  • Fig. S1. Photographs of the iSAVE setup.
  • Fig. S2. Differential tidal volume and PEEP delivery on the iSAVE using an open-circuit ventilator and test lungs.
  • Fig. S3. Accommodation to changes in compliance of one test lung using the iSAVE and an open-circuit ventilator.
  • Fig. S4. Ventilation at high lung resistances.
  • Fig. S5. Ventilator alarm response to occlusion.
  • Fig. S6. Adding a test lung to the circuit.
  • Fig. S7. Cross-contamination validation using artificial lungs on a closed-circuit ventilator.
  • Fig. S8. Individualized management of ventilation using the iSAVE on a pig lung and a test lung.
  • Fig. S9. Modification of sensing circuit for a Hamilton G5 ventilator.
  • Fig. S10. Whistle ring designs for two types of common pressure release (PEEP) valves.
  • Table S1. List of components required for the assembly of the iSAVE.
  • Table S2. Mechanical components used in the iSAVE and their readily available medical industry equivalents.
  • Table S3. Measurement of respiratory mechanics for iSAVE system using test lungs.
  • Table S4. Blood electrolytes and chemistry during ventilation in pigs.
  • Table S5. Stratification for patient matching.

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