Supplementary Materials
The PDF file includes:
- Fig. S1. Humoral responses elicited by immunization with PbVac.
- Fig. S2. Frequency of subfamilies of circulating immune cells.
- Fig. S3. Serum concentration of cytokines and chemokines after the first PbVac administration.
- Fig. S4. Polyfunctionality of CD4+ T cell–produced cytokines.
- Fig. S5. Polyfunctionality of cross-species cytokine responses.
- Fig. S6. Analysis of heterogeneity of individual responses to immunization.
- Table S1. Baseline characteristics.
- Table S2. Adverse events.
- Table S3. Laboratory abnormalities.
- Table S4. Correlation between humoral responses elicited by PbVac, total number of mosquito bites after four immunizations, and CHMI outcome.
- Table S5. Correlation between changes in frequency of circulating subfamilies of immune cells, total number of mosquito bites after four immunizations, and CHMI outcome.
- Table S6. Correlation between changes in serum cytokine levels after the first PbVac administration, total number of mosquito bites after four immunizations, and CHMI outcome.
- Table S7. Correlation between changes in serum cytokine levels 10 days after the first PbVac administration and changes in frequency of circulating subfamilies of immune cells before CHMI.
Other Supplementary Material for this manuscript includes the following:
- Data file S1 (.pdf format). Clinical protocol.
- Data file S2 (Microsoft Excel format). Primary data.