Supplementary Materials

The PDF file includes:

• Fig. S1. Humoral responses elicited by immunization with PbVac.
• Fig. S2. Frequency of subfamilies of circulating immune cells.
• Fig. S3. Serum concentration of cytokines and chemokines after the first PbVac administration.
• Fig. S4. Polyfunctionality of CD4⁺ T cell–produced cytokines.
• Fig. S5. Polyfunctionality of cross-species cytokine responses.
• Fig. S6. Analysis of heterogeneity of individual responses to immunization.
• Table S1. Baseline characteristics.
• Table S2. Adverse events.
• Table S3. Laboratory abnormalities.
• Table S4. Correlation between humoral responses elicited by PbVac, total number of mosquito bites after four immunizations, and CHMI outcome.
• Table S5. Correlation between changes in frequency of circulating subfamilies of immune cells, total number of mosquito bites after four immunizations, and CHMI outcome.
• Table S6. Correlation between changes in serum cytokine levels after the first PbVac administration, total number of mosquito bites after four immunizations, and CHMI outcome.
• Table S7. Correlation between changes in serum cytokine levels 10 days after the first PbVac administration and changes in frequency of circulating subfamilies of immune cells before CHMI.

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Other Supplementary Material for this manuscript includes the following:

• Data file S1 (.pdf format). Clinical protocol.
• Data file S2 (Microsoft Excel format). Primary data.