Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. ATRAID is required for the cellular responses to N-BPs.
  • Fig. S2. Generation and skeletal characterization of AtraidKO mice.
  • Fig. S3. Atraid is required cell autonomously for the effects of N-BP on osteoclasts in two models of osteoporosis.
  • Legends for data files S1 to S4
  • References (5281)

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Results of haploid genomic screen for genes required for the response to alendronate.
  • Data file S2 (Microsoft Excel format). Statistics for AtraidKO mice basal characterization and statistics for bone structure and strength of ovariectomized wild-type and AtraidKO animals treated with alendronate.
  • Data file S3 (Microsoft Excel format). Statistics for bone histomorphometry and serum bone proteins in ovariectomized and senile wild-type and AtraidKO animals treated with alendronate.
  • Data file S4 (Microsoft Excel format). Gene expression, sequencing, and cell growth phenotype data for ONJ, DTC, AFF, and CRISPRi/a studies.