Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. PXR deficiency aggravated cisplatin-induced tubular inflammation and mitochondrial damage.
  • Fig. S2. MnTBAP therapy attenuated cisplatin-induced AKI in wild-type and PXR−/− rats.
  • Fig. S3. PCN treatment ameliorated cisplatin-induced apoptosis, inflammation, and the dysregulation of mitochondrial genes in vitro.
  • Fig. S4. PXR overexpression attenuated cisplatin-induced apoptosis and mitochondrial dysfunction in vitro.
  • Fig. S5. PCN treatment or PXR overexpression attenuated cisplatin-induced apoptotic response in three-dimensional cultured HK2 cells.
  • Fig. S6. Expressions of other nuclear receptors remained unchanged in PXR−/− rats.
  • Fig. S7. AKR1B7 overexpression prevented cisplatin-induced mitochondrial injury in vitro.
  • Fig. S8. PXR deficiency changed mitochondrial metabolic pathways.
  • Fig. S9. PXR/AKR1B7 activation attenuated cisplatin-induced lipid accumulation and improved mitochondrial fatty acid β-oxidation.
  • Fig. S10. The protective effect of PXR on mitochondrial oxidative capacity and fatty acid β-oxidation was diminished by silencing AKR1B7.
  • Fig. S11. PXR deficiency aggravated I/R-induced mitochondrial damage.
  • Table S1. Clinical data of patients with AKI.
  • References (4754)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Primary data.
  • Data file S2 (Microsoft Excel format). Proteomics analysis of all differential proteins between wild-type and PXR−/− groups.
  • Data file S3 (Microsoft Excel format). Untargeted lipidomics analysis of all differential lipids between wild-type and PXR−/− groups.
  • Data file S4 (Microsoft Excel format). Untargeted metabolomics analysis of all differential metabolites between wild-type and PXR−/− groups.
  • Data file S5 (Microsoft Excel format). RNA-seq analysis of all differential transcriptomes between NC and AKR1B7-overexpressed RTECs.
  • Data file S6 (Microsoft Excel format). Primers used for PCR amplification.