Supplementary Materials

The PDF file includes:

  • Fig. S1. Metabolic phenotypes of lactating and lactated mice.
  • Fig. S2. β Cell characteristics during and after lactation.
  • Fig. S3. Ex vivo glucose-stimulated insulin secretion of isolated islets from lactating/lactated mice.
  • Fig. S4. The specificity and efficiency of Cre lines.
  • Fig. S5. Metabolic phenotypes of Tph1 βiKO mice.
  • Fig. S6. Metabolic phenotypes of Htr2b βKO mice.
  • Fig. S7. Establishment of Tph1-null MIN6 cell line and antioxidant properties of 5-HT.
  • Fig. S8. Schematic summary of this study.
  • Table S1. Baseline characteristics and glycemic profiles during gestation.
  • Table S2. Glycemic profiles of the 75-g OGTT during and after lactation.
  • Table S3. Primer sequences for genotyping.
  • Table S4. Primer sequences for qRT-PCR and CRISPR KO.

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Other Supplementary Material for this manuscript includes the following: