Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. DR5 was up-regulated in rat heart after I/R.
  • Fig. S2. The sDR5-Fc fusion protein and DR5 expression in the heart.
  • Fig. S3. The dose-dependent cardioprotective effect of sDR5-Fc in rats.
  • Fig. S4. The cardioprotective effect of anti-DR5 mAb in rats.
  • Fig. S5. Characterization of DR5−/− rats.
  • Fig. S6. TUNEL and IHC for caspase 3 and caspase 8.
  • Fig. S7. The effect of sDR5-Fc on Bcl-2 family expression in vivo and TRAIL-mediated cell death in vitro.
  • Fig. S8. Quantification of primary cardiomyocyte apoptosis.
  • Fig. S9. IHC for CD68 and MPO.
  • Fig. S10. Neutrophil and macrophage depletion in rats.
  • Fig. S11. TRAIL-expressing cells identified by flow cytometry.
  • Legends for tables S1 and S2
  • Table S3. The sequence of primers used in this study.
  • Legend for data file S1
  • References (5460)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). RNA-seq analysis of sham versus I1/R3h rats.
  • Table S2 (Microsoft Excel format). RNA-seq analysis of sham versus I1/R24h rats.
  • Data file S1 (Microsoft Excel format). Raw data.