Supplementary Materials

The PDF file includes:

• Fig. S1. Assessment of cytotoxicity of NHC in primary human epithelial cell cultures by qRT-PCR.
• Fig. S2. High conservation of RdRp functional domains for SARS-CoV-2.
• Fig. S3. Prophylactic EIDD-2801 reduces SARS-CoV replication and pathogenesis.
• Fig. S4. Prophylactic EIDD-2801 reduces MERS-CoV replication and pathogenesis.
• Table S1. Real-time PCR primer/probe sets for indicators of cellular apoptosis/toxicity.
• Table S2. Primers used for MiSeq library prep and sequencing.

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Other Supplementary Material for this manuscript includes the following:

• Data file S1 (Microsoft Excel format). Primary data.