Supplementary Materials

The PDF file includes:

  • Fig. S1. Influence of different salt concentrations on UPEC growth and measurement of urine excretion.
  • Fig. S2. No influence of an HSD on intrarenal cytokine production and neutrophil numbers.
  • Fig. S3. Sodium staining in kidney neutrophils.
  • Fig. S4. High salt effect on macrophages and T cells.
  • Fig. S5. HSD effect on steroid biosynthesis and urea effect on Nfat5.
  • Fig. S6. Effect of urea on macrophage function.
  • Fig. S7. Antisense oligonucleatide-mediated NFAT5 knockdown in the kidney.
  • Fig. S8. An HSD does not cause major changes in serum and urine glucose concentrations.
  • Fig. S9. Effect of dexamethasone on macrophage function.
  • Fig. S10. Measuring intraphagosomal pH.
  • Fig. S11. An HSD impairs the defense against Listeria in the liver.
  • Fig. S12. Epidemiologic correlation between human salt intake and UTI incidence in various countries.
  • Fig. S13. Mechanism of HSD-mediated glucocorticoid increase and pyelonephritis/listeriosis exacerbation.
  • Fig. S14. Validation of the method to measure UPEC phagocytosis.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). GO analysis of genes down-regulated in bone marrow neutrophils upon HSD exposure.
  • Data file S1 (Microsoft Excel format). Primary data.