Supplementary Materials

This PDF file includes:

  • Methods
  • Fig. S1. QWBA of CDP-11R in rats.
  • Fig. S2. HPLC analysis of 14C-CDPs.
  • Fig. S3. Chemical structures of CDP constructs.
  • Fig. S4. HPLC analysis of CDP constructs.
  • Fig. S5. Standard curve calibration of radioactive standards.
  • Table S1. Individual subject data for spleen weight in the CDP-11R–DMA–dex pharmacokinetic study.
  • Table S2. Individual subject data for thymus weight in the CDP-11R–DMA–dex pharmacokinetic study.
  • Table S3. Individual subject data for dex quantification in plasma.
  • Table S4. Individual subject data for the CDP-11R–DMA–TAA rat CIA efficacy study.
  • Table S5. Validation of recombinant protein amino acid composition and mass.
  • Table S6. Crystallization conditions.
  • Table S7. Predicted isoelectric point of CDPs.
  • Table S8. Radiochemical purities of 14C-CDPs by HPLC.

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