Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. FSP-1 expression in GBM-associated ECs.
  • Fig. S2. Chemoresistance in GBM-associated ECs.
  • Fig. S3. Expression of c-Kit and CD44 in GBM ECs.
  • Fig. S4. Dil-Ac-LDL uptake in sphere-forming GBM ECs.
  • Fig. S5. Differentiation of GBM ECs into mesenchymal cells.
  • Fig. S6. MSC-like trilineage differentiation of GBM ECs.
  • Fig. S7. Correlation of stemness activation and mesenchymalization with chemoresistance in GBM ECs.
  • Fig. S8. Effects of FOXO1 or FLF4 knockdown on chemoresistance in ECs.
  • Fig. S9. LEF1 transcriptional activation in ECs cocultured with GBM cells.
  • Fig. S10. Expression of Wnt target genes in ECs.
  • Fig. S11. Chemoresistance in ECs treated with glioma-CM.
  • Fig. S12. CRISPR-mediated β-catenin knockdown in ECs.
  • Fig. S13. Effects of HGF or Wnt5a neutralization on chemoresistance in ECs.
  • Fig. S14. A schematic model.
  • Fig. S15. Cdh5-CreERT2–mediated β-catenin knockdown in ECs.
  • Fig. S16. Effects of β-catenin knockdown in ECs on GBM response to chemotherapy.
  • Fig. S17. Effects of Wnt inhibition on EC chemoresistance and EC-mediated glioma cell chemoresistance.
  • References (9196)

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Other Supplementary Material for this manuscript includes the following: